ШАЙФЛИНГЕР Фридрих,ТУРЕЦЕК Петер,ЭВЕНШТАЙН Брюс,ВОНГ Винг Йен,СУИТЕР Тобиас М.
申请号：
RU2014100107
公开号：
RU2014100107A
申请日:
2012.06.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method for treating von Willebrand disease or hemophilia A patient in need of treatment comprising: administering a recombinant vWF (rFV) so that the time is prolonged half-life of factor VIII, compared with patients who were administered Willebrand factor obtained from plasma, with this is rFV composition of high-molecular vWF multimers, containing at least 20% of the PV decamers or higher order multimers, at what rFV has a higher specific activity than the von Willebrand factor obtained from plasma krovi.2. A method according to Claim. 1, which method comprises co-administration to a patient of recombinant vWF (rFV) and recombinant Factor VIII (rFVIII) .3. The method of claim. 2, and wherein rFV pFVIII administered together in one sostave.4. A method according to any one of claims. 1-3, in which the patient is administered 1.0 IU / kg of vWF: RCO to 150 IU / kg of vWF: RCO on dozu.5. . A method according to claim 4, wherein the patient is administered from 2 IU / kg FW: RKO to 50 IU / kg FW: RKO on dozu.6. . A method according to claim 4, wherein the patient is administered between 5 IU / kg FW: RKO to 40 IU / kg FW: RKO on dozu.7. . A method according to claim 4, wherein the patient is administered from 10 IU / kg FW: RKO to 20 IU / kg FW: RKO on dozu.8. A method according to any one of claims. 1-3, 5-7, wherein the in vitro matured rFV furinom.9 during processing. A method according to any one of claims. 1-3, 5-7, wherein rFV is obtained by expression in Chinese hamster ovary (CHO cell culture) .10. The method of claim. 1-3, 5-7, and wherein pFVIII rFV is obtained by expression in the same cell kulture.11. A method according to any one of claims. 1-3, 5-7, in which the patient is administered rFV no more frequently than once a den.12. The method of claim. 11 wherein the patient is administered rFV no more frequently than twice a nedelyu.13. A method according to any one of claims. 1-3, 5-7, 12, wherein the SOS1. Способ лечения болезни Виллебранда или гемофи
