The object of the present invention is to promote bone formation, improves bone metabolism, fractures to prevent or treat, prevent or treat a disease associated with bone metabolism, or, fracture orthopedic area, promoting healing of bone diseases such as bone loss and osteoarthritis, and, periodontal disease in the dental field and it is to provide a compound or a pharmacologically acceptable salt thereof are used to stabilize the therapeutic or artificial tooth root. Its solving means are described below, is generally a compound having the formula (I) or a pharmacologically acceptable salt thereof. [Formula 1] [it shows each substituent in the formula below. R1: such as a halogen atom, R2: such as a hydrogen atom, R3: such as a hydrogen atom, R4: such as a hydrogen atom, A: heterocyclic group]本発明の課題は、骨形成を促進し、骨代謝を改善し、骨折を予防又は治療し、骨代謝に関連する疾患を予防又は治療し、又は、整形外科領域の骨折、骨欠損及び変形性関節症などの骨疾患の治癒促進、及び、歯科領域における歯周病治療や人工歯根の安定化するために用いられる化合物又はその薬理上許容される塩を提供することである。 その解決手段は、下記、一般式(I)を有する化合物又はその薬理上許容される塩である。【化1】[式中の各置換基を以下に示す。R1:ハロゲン原子等、R2:水素原子等、R3:水素原子等、R4:水素原子等、A:複素環基等]
