An object of the present invention is to provide a novel compound having high pharmacological activity and safety and having bone metabolism inhibiting activity. One embodiment of the present invention is one in which formula (I) [wherein R1, R2, R3, and R4 have the same meanings as defined in the specification or claims. ] It is related with the compound represented by these, its salt, or those solvates. Another aspect of the present invention is a method for producing a compound represented by the formula (I), a microorganism capable of producing the compound, a bone metabolism inhibitor containing the compound as an active ingredient, and the compound effective. It also relates to a medicament or pharmaceutical composition comprising as an ingredient. [Selection diagram] None【課題】本発明は、薬理活性及び安全性の高い、骨代謝阻害活性を有する新規化合物を提供することを課題とする。【解決手段】本発明の一態様は、式（I）［式中、R1、R2、R3及びR4は、明細書又は特許請求の範囲に記載の定義と同義である。］で表される化合物若しくはその塩、又はそれらの溶媒和物に関する。本発明の別の一態様は、式（I）で表される化合物の製造方法、該化合物を産生する能力を有する微生物、該化合物を有効成分として含む、骨代謝阻害剤、並びに該化合物を有効成分として含む医薬又は医薬組成物にも関する。【選択図】なし
