The object of this invention is to provide a compound or a pharmacological acceptable salts thereof, which can be utilized for promotion of bone formation, improvement of bone metabolism, prevention or treatment of a bone fracture, prevention or treatment of a disease associated with bone metabolism, or promotion of treatment of bone diseases such as bone fractures, bone defects, osteoarthritis in the plastic surgery field, and periodontal treatment as well as artificial tooth roots stabilization in the dental field. The solution way according to this invention is to provide a compound having the following general formula (I) or the pharmacological acceptable salts thereof.[substituted groups in the formula are listed as follows.R1: a halogen atom and so on, R2: a hydrogen atom and so on, R3: a hydrogen atom and so on, R4: a hydrogen atom and so on, A: a heterocyclic group and so on].本發明之課題在於提供促進骨形成、改善骨代謝、預防或治療骨折、預防或治療骨代謝相關之疾病、或於整形外科領域之骨折、骨缺損及變形性關節病等骨疾病之治癒促進、及於牙科領域之牙周病治療或人工牙根之安定化可使用之化合物或其在藥理上可容許之鹽。本發明之解決方法係下列具有通式(I)之化合物或其在藥理上可容許之鹽。[式中之各取代基如以下所示,R1:鹵素原子等、R2:氫原子等、R3:氫原子等、R4:氫原子等、A:雜環基等]
