CHAPPIE, THOMAS ALLEN,GALATSIS, PAUL,GARNSEY, MICHELLE RENEE,HELAL, CHRISTOPHER JOHN,HENDERSON, JACLYN LOUISE,KORMOS, BETHANY LYN,KURUMBAIL, RAVI G.,MARTINEZ-ALSINA, LUIS ANGEL,PETTERSSON, MARTIN YOUN
申请号：
CA3056027
公开号：
CA3056027A1
申请日:
2018.03.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides novel cyclic substituted imidazo[4,5- c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
