The present invention relates to 2&prime-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2&prime-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2&prime-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.