BOCK, MARK G.,CHIKKANNA, DINESH,MCCARTHY, CLIVE,MOEBITZ, HENRIK,PANDIT, CHETAN
申请号：
PE0006082012
公开号：
PE14712012A1
申请日:
2010.11.02
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of Heterocyclic sulfonamide Derivative of formula (i) where: A1A and r1b are hydroxyl alkyl, cyano, Nitro, C1 C2 - 6 - 6, alquenilo, among others 2a is H or alkyl of C1 - 6 R2B is C1 - C2 alquenilo 6 alkyl, cycloalkyl, aryl, - 6 among Others, R3 and R4 are C1 - 6 h, alkyl, alkyl C1 - 6 or optionally substituted by Halogen, alkoxyl hidroxialquilo C1 and C1 - 6 - 6, R5 is H, halogen,C1-3 alkyl or Halogen substituted c1-3 alkyl X is N (r6), R6 is H or alkyl of C1 - 6 W is nr22 S. R22 is H, or C1, C2 alquenilo alkyl - 6 - 6, cycloalkyl, aryl, among others.Preferred compounds are: [6 - (4 - bromo - fluoro - phenyl - 2 - amino) - 6 - methyl - 5 - oxo - - One, two, three, Six - tetrahydro imidazo [1,2-a] - pyridin - il - 8] - ciclopropan - sulfonic acid amide 7 - [(2 - 4 - fluoro Iodine - amino phenyl) - 6 - methyl - 5 - oxo - - One, two, three, Six - tetrahydro imidazo [1,2-a] pyridin - il - 8 - amide acid] - 1 - (2,3-dihydroxy propyl) - ciclopropan - sulfonic acid, among others. It also relates to a Pharmaceutical composition.This Compound is an inhibitor of protein kinase MEK being useful in the treatment of hyperproliferative diseases such as Cancer and inflammationSE REFIERE A UN COMPUESTO DERIVADO DE SULFONAMIDA HETEROCICLICO DE FORMULA (I) DONDE: R1a Y R1b SON HIDROXILO, CIANO, NITRO, ALQUILO C1-6, ALQUENILO C2-6, ENTRE OTROS R2a ES H O ALQUILO C1-6 R2b ES ALQUILO C1-6, ALQUENILO C2-6, CICLOALQUILO, ARILO, ENTRE OTROS R3 Y R4 SON H, ALQUILO C1-6, ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO POR HALOGENO, HIDROXIALQUILO C1-6 O ALCOXILO C1-6, R5 ES H, HALOGENO, ALQUILO C1-3 O ALQUILO C1-3 SUSTITUIDO POR HALOGENO X ES -N(R6)- R6 ES H O ALQUILO C1-6 W ES NR22, O O S. R22 ES H, ALQUILO C1-6, ALQUENILO C2-6, CICLOALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [7-(4-BROMO-2-FLUORO-FENIL-AMINO)-6-METIL-5-OXO-1,2,3,5-TETRAHIDRO-IMIDAZO-[1,2-a]-PIRIDIN-8-IL]-AMIDA DEL ACIDO CICLOPROPAN-SULFONICO [7-(2-FLUORO-4-YODO-FENIL-AMINO)-6-METIL-5-OXO-1,2,3,5-TET
