PARTON ANDREW HARRY,ALI MEZHER HUSSEIN,BROOKINGS DANIEL CHRISTOPHER,BROWN JULIEN ALISTAIR,FORD DANIEL JAMES,FRANKLIN RICHARD JEREMY,LANGHAM BARRY JOHN,NEUSS JUDI CHARLOTTE,QUINCEY JOANNA RACHEL
申请号：
ARP110103154
公开号：
AR082799A1
申请日:
2011.08.30
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
That are Selective inhibitors of PI3 kinase Enzymes are thus beneficial in Medicine, for example in the treatment of inflammatory conditions, autoimmune, neurodegenerative, cardiovascular, oncological, Metabolic, nociceptive or ophthalmic.Claim 1: a compound of formula (1) or one of its N - oxides, or one of its Salts or solvates acceptable from the point of view or pharmacist wherein represents - CF3, - or - CHF2 CH2f； Q represents Oxygen, Sulphur, N - R4 or a Covalent Bond； Z represents a rest heteroaryl Substituted bicyclic optionally which consists of two FUSED Aromatic Rings of six members,The Rest heteroaryl z that contains at least one nitrogen Atom and is linked to the rest of the Molecule through a carbon Atom； M represents aryl or heteroaryl groups, any of which may be optionally substituted by one or more substituents； W represents C R5 or N； R1, R2 and R3 are independently Hydrogen, halogen, Nitro, cyano,Cicloalquil trifluoromethyl alkyl C1 - C3 - 6, 7 - 6 heterocicloalquil alkyl C1 - C3, C1 - 6 - 7 - alkyl, arylalkyl heteroarilalquilo C1 C1 - 6 - 6, 6 - hydroxy, alkoxy Difluoromethoxy trifluoromethoxy, C1, C1, C1 alquilsulfinilo Alquiltio - 6 - 6, 6 - amino alquilsulfonilo C1,. Alquilamino dialquilamino C1 C1 - 6 - 6 Alquilcarbonilamino alcoxicarbonilamino C2 C2 - 6, - 6, - 6 alquilsulfonilamino C1, Formilo,Alquilcarbonilo C2 C2 alcoxicarbonilo carboxy, - 6, - 6, - 6 aminocarbonilo alquilaminocarbonilo C1, C1 -, di - alquilaminocarbonilo aminosulfonilo alquilaminosulfonilo C1, 6, 6 - Di - or alquilaminosulfonilo C1 - 6； R4 represents Hydrogen or alkyl of C1 - 6； and R5 is Hydrogen, halogen, alkyl of C1 - 6 or ALCO XI C1 - 6.Que son inhibidores selectivos de enzimas de quinasa PI3, son en consecuencia beneficiosos en medicina, por ejemplo en el tratamiento de afecciones inflamatorias, autoinmunes, cardiovasculares, neurodegenerativas, metabólicas, oncológicas, nociceptivas u oftálmicas.Reivindicación 1: Un compuesto de fórmula (1) o uno de sus N-óxidos,
