BARLAAM, BERNARD CHRISTOPHE,DEGORCE, SEBASTIEN LOUIS,LAMBERT-VAN DER BREMPT, CHRISTINE MARIE PAUL,MORGENTIN, REMY ROBERT,PLE, PATRICK
申请号：
PE0005782012
公开号：
PE01492013A1
申请日:
2010.10.25
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Cromenona refers to compounds of formula (i) wherein R1 is H or alkyl (c1-c4) optionally substituted by Halogen, Hydroxy or alkoxy (C1 - C3) R2 is alkyl (c1-c4) (C1 - C4) or alkoxy optionally substituted by Halogen, Hydroxy, alquenilo (C2 - C3), among others R3 is H or alkyl (C1 - C3) R4 and R5 are each h, halogen, alkyl (C1 - C3) alquenilo (C2, C3), CN, R6, among othersR7 and R8 are each h, halogen, alkyl, alkoxy (C1 - C3) (C1 - C3), among others R9 is alkyl (C1 - C3) n is 0 to 4.Preferred compounds are: N - (2 - (dimethylamino) ethyl) - 2 - (1 - (4 - fluorofenilamino morpholino) ethyl) - 2 - 4 - oxo 4h chromene - 6 - carboxamide n - (2 - (dimethylamino) ethyl) - 2 - oxo - morpholino - 4 - 8 - (1 - (phenylamino) - ethyl) - 4H chromene - 6 - carboxamide 8 - (1 - (3 - Chloro - 2 - fluorofenilamino) ethyl) - N - (2 - (dimethylamino) ethyl) - 2 - 4 - morpholino Ox Or - 4H chromene - 6 - carboxamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of phosphoinositide 3-kinase (PI)? To be useful in the treatment of cancerSE REFIERE A COMPUESTOS DERIVADOS DE CROMENONA DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI O ALCOXI(C1-C3) R2 ES ALQUILO(C1-C4) O ALCOXI(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI, ALQUENILO(C2-C3), ENTRE OTROS R3 ES H O ALQUILO(C1-C3) R4 Y R5 SON CADA UNO H, HALOGENO, ALQUILO(C1-C3), ALQUENILO(C2-C3), CN, ENTRE OTROS R6, R7 Y R8 SON CADA UNO H, HALOGENO, ALQUILO(C1-C3), ALCOXI(C1-C3), ENTRE OTROS R9 ES ALQUILO(C1-C3) n ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: N-(2-(DIMETILAMINO)ETIL)-8-(1-(4-FLUOROFENILAMINO)ETIL)-2-MORFOLINO-4-OXO-4H-CROMENO-6-CARBOXAMIDA N-(2-(DIMETILAMINO)ETIL)-2-MORFOLINO-4-OXO-8-(1-(FENILAMINO)ETIL)-4H-CROMENO-6-CARBOXAMIDA 8-(1-(3-CLORO-2-FLUOROFENILAMINO)ETIL)-N-(2-(DIMETILAMINO)ETIL)-2-MORFOLINO-4-OXO-4H-CROMENO-6-CARBOXAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE FO
