BARBOSA Antonio Dzh. M. (US),БАРБОСА Антонио Дж. М. (US),BLOMGREN Piter A. (US),БЛОМГРЕН Питер А. (US),KURRI Kevin S. (US),КУРРИ Кевин С. (US),KRISHNAMURTI Ravi (US),КРИШНАМУРТИ Рави (US),KROPF Dzheff,BARBOSA Antonio Dzh. M.,БАРБОСА Антонио Дж. М.,BLOMGREN Piter A.,БЛОМГРЕН Питер А.,KURRI Kevin S.,КУРРИ Кевин С.,KRISHNAMURTI Ravi,КРИШНАМУРТИ Рави,KROPF Dzheffri E.,КРОПФ Джеффри Е.,LI Seng KH.,ЛИ Сё
申请号：
RU2012152548
公开号：
RU0002617405C2
申请日:
2011.05.06
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound selected from formula I, or its stereoisomers, or pharmaceutically acceptable salts thereof, where R1 is optionally substituted C1-C3 alkyl； R2, R3 and R4 are independently selected from H, F, Cl； R5 is selected from (i) optionally substituted C6-C20 aryl, selected from phenyl； (ii) optionally substituted C5-C20 heteroaryl, selected from pyrazolyl, pyridinyl, pyrimidinyl, tetrahydroisoquinolinyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazinyl, 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazinyl, 4,6,7-trihydropyrazolo[3,2-c][1,4]oxazinyl, 5,6,7,8-tetrahydro-1,6-naphthyridinyl, 2,3-dihydro-1H-isoindolyl, 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridinyl； (iii) optionally substituted -(C6-C20 aryl)-(C3-C20 heterocyclyl), where heterocyclyl is selected from azetidinyl, piperidinyl, morpholino, piperazinyl； (iv) optionally substituted -(C5-C20 heteroaryl)-(C3-C20 heterocyclyl), where heteroaryl is selected from pyridinyl and pyridazinyl and heterocyclyl is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, 1,4-diazepanyl, 2,6-diazaspiro[3.3]heptanyl, 7,9-diazabicyclo[3.3.1]nonanyl, hexahydropyrrolo[3,4-c]pyrrolyl, morpholino； (v) optionally substituted -(C5-C20 heteroaryl)-(C1-C6 alkyl), where heteroaryl is selected from pirazolyl and pyridinyl； or (vi) optionally substituted -(C5-C20 heteroaryl)-C(=O)-(C3-C20 heterocyclyl), selected from (pyridinyl)-C(=O)-(morpholino)； R6 represents H or C1-C3 alkyl； Y1 and Y2 are independently selected from CR6 and N； where C1-C3 alkyl, C3-C20 heterocyclyl, C6-C20 aryl and C5-C20 heteroaryl optionally substituted with one to three groups, independently selected from D, F, Cl, Br, I, -CH3, -CH2CH3, -CH2CH(CH3)2, -CH2OH, -CH2CH2OH, -C(CH3)2OH, -CH2F, -OC(O)CH3, -COCH3, -NHCH3, -N(CH3)2, =O, -OH, -OCH3, -OCH2CH2N(CH3)2, -OP(O)(OH)2, -CH2OCH3, cyclopropyl, azetidinyl, 1-(methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, oxetanyl and morpholino； where group (a
