YANG, Wu,CORTE, James,GILLIGAN, Paul,PINTO, Donald,EWING, William,DILGER, Andrew,WANG, Yufeng,FANG, Tianan,PABBISETTY, Kumar,SMITH II, Leon
申请号：
ES13747625
公开号：
ES2623175T3
申请日:
2013.08.02
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (XI): ** ** Formula or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein: ring A is independently selected from a 6-membered aryl and 5- to 6 members, wherein said aryl and heterocycle are substituted with 1-4 R4 ring B is independently selected from a 6-membered aryl and a 5- to 10-membered, wherein said aryl and heterocycle are substituted with 1-4 R3 G1 is independently selected from a C3-10 carbocycle and a 5- to 10-membered carbocycle wherein said heterocycle and 1-4 are substituted with R8 X1 is independently selected from CR7 and N - - - is an optional bond Y is independently selected from -NH-C (O) - and -C (O) -NH- R1 and R2 are independently selected from H, halogen, haloalkyl, C1-4 alkyl (optionally substituted with R6), hydroxy and alkoxy (optionally substituted with R6) and C3-5 cycloalkyl optionally substituted with R6 R3 is independently selected from H,> = O, halogen, haloalkyl, C1-4 alkyl (optionally substituted with R6), C2-4 alkenyl (optionally substituted with R6), C2-4 alkynyl (optionally substituted with R6), CN, NO2, - (CH2) n-OR5, - (CH2) n-NR5R5, - (CH2) nC (O) OR5, - (CH2) n-NR 9 C (O) OR5, - (CH2) n-NR 9 C (O) R5, - (CH2) n-NR 9 C (NCN) NHR 5, - (CH 2) n NR 9 C (NH) NHR 5, - (CH2) nN> = CR9NR5R5, - (CH 2) n NR 9 C (O) NR5R5, - (CH2 ) nC (O) NR5R5, - (CH2) n- NR 9 C (S) NR 9 C (O) R5, - (CH2) nS (O) p R 12, - (CH2) nS (O) pNR5R5, - (CH2) n-NR 9 (O) pNR5R5, - (CH2) n-NR 9 S (O) p R 12, - (CH2) n-C3-10 carbocycle and - (CH2) n-heterocycle of 4 to 10 members, wherein said carbocycle and heterocycle are optionally substituted with R6 optionally, two adjacent groups R3 on the carbocycle and the heterocycle may form a ring optionally substituted with R6. R4 is independently selected from H, OH, halogen, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, -C (O) NH2, -C (O) NH (C1-4 alkyl), -C (O) N (C1-4alkyl) 2, C3-6cycloalkyl, aryl and 5- to 6-membered, wherein said cycloalkyl, aryl and heterocycle a
