GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
CHARNLEY, Adam Kenneth,DARCY, Michael G.,DODSON, Jason W.,DONG, Xiaoyang,HUGHES, Terry V.,KANG, Jianxing,LEISTER, Lara Kathryn,LIAN, Yiqian,LI, Yue,MEHLMANN, John F.,NEVINS, Neysa,RAMANJULU, Joshi M.
申请号：
PE0023222018
公开号：
PE19202018A1
申请日:
2017.04.05
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Refers to a compound of formula I - n, where q is 0 OR 1, R is 0 OR 1, s is 0 OR 1 when q is 0, ra1 and RA2 are h, halogen, Hydroxy, or - P (o) (OH) 2, among others when r is 0,RB1 and RB2 can be H c1-c6 alkyl, optionally substituted, alquenilo C2 - C6 optionally replaced, among others when s is 0, RC1 is H,Halogen or c1-c4 alkyl and RC2 is c1-c4 alkyl, optionally substituted, a, B and C are - C12 alkyl R1, R3 and R5 are each independently is H, COOH,Among others, R4 and R6 can be independently h, halogen, Halo (alquiloc1 - C6), among others, R14 is c1-c4 alkyl, optionally substituted R16 is H,C1-c4 alkyl or Halogen R15 and R17 are each independently h, ciclopropilo or c1-c4 alkyl.Preferred Compound is (e) - 1 - (4 - (5 - (carbamoyl - 1 - 2 - 3 - methyl - ethyl) - 1H pyrazole - 5 - carboxamido) - 1H benzo [d] imidazol-1-yl) but - 2 - in - 1 - 1 - 2 - (IL) - ethyl - 3 - Methyl - 5 - 1H pyrazole carboxamido) - 7 - (3 - hidroxipropoxi) - 1HBenzo [d] - 5 - imidazole carboxamide among others. It also relates to a Pharmaceutical Formulation and a method of treatment.These compounds are useful as modulators of the transmembrane Protein (173 TMEM173) also known as Sting (Stimulator of interferon genes),And is useful in the treatment of allergic diseases such as Asthma and allergic rhinitis, among othersSe refiere a un compuesto de formula I-N, en donde q es 0 o 1, r es 0 o 1, s es 0 o 1 cuando q es 0, RA1 y RA2 pueden ser H, halogeno, hidroxi, -O-P(O)(OH)2, entre otros cuando r es 0, RB1 y RB2 pueden ser H, alquilo C1-C6 opcionalmente sustituido, alquenilo C2-C6 opcionalmente sustituido, entre otros cuando s es 0, RC1 es H, halogeno o alquilo C1-C4 y RC2 es alquilo C1-C4 opcionalmente sustituido, A, B y C son alquilos C1-C12, R3 y R5 son cada uno independientemente es H, COOH, entre otros R4 y R6 pueden ser independientemente H, halogeno, halo(alquiloC1-C6), entre otros R14 es alquilo C1-C4 opcionalmente sustituido R16 es H, halogeno o alquilo C1-C4 R15 y R17 son cada uno i
