BACON, Elizabeth M.,BRIZGYS, Gediminas,CHIN, Elbert,CHOU, Chienhung,COTTELL, Jeromy J.,LINK, John O.,TAYLOR, James G.,TSE, Winston C.,WRIGHT, Nathan E.,YANG, Zheng-Yu,ZHANG, Jennifer R.,ZIPFEL, Sheila
申请号：
PE2019001681
公开号：
PE20191540A1
申请日:
2018.02.15
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
This compound includes: C1-C10 tar such as C1-C10, c13-c10, arilo C6-C10, etc.； R3 and R4 tar such as h, halo, NO2, c1-c9, etc.； R5, R6 and R7 tar such as h, halo, CN, NO2, etc.； Z1 tar such as oxo, halo, NO2, CN, etc. A pharmaceutical composer was also mentioned These compounds are inhibitors of Iraqi pentachloromethane and can be used to treat inflammation.Referida a compuestos derivados de pirrolopiridazina de formula (I), donde: R1 y R2 son alquilo C1-C10, cicloalquilo C3-C10, arilo C6-C10, entre otros； R3 y R4 son H, halo, NO2, alquilo C1-C9, entre otros； R5, R6 y R7 son H, halo, CN, NO2, entre otros； Z1 es oxo, halo, NO2, CN, entre otros. Tambien esta referida a una composicion farmaceutica. Dichos compuestos son inhibidores de la quinasa IRAK4 y son utiles en el tratamiento de trastornos inflamatorios
