FLIRI, ANTON FRANZ JOSEPH,GALLASCHUN, RANDALL JAMES,ODONNELL, CHRISTOPHER JOHN,SCHWARZ, JACOB BRADLEY,SEGELSTEIN, BARBARA EILEEN
申请号：
ES10732448
公开号：
ES2517267T3
申请日:
2010.06.22
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula I, or a pharmaceutically acceptable salt thereof, ** ** Formula wherein each R1, each R2 and each R7 is independently selected from the group consisting of hydrogen, halogen, hydroxyl, -CF3, -CN , - (C> = O) R8, -O- (C> = O) -R 8, - (NR8) - (C> = O) -R8, - (CO) -OR 8, - (C> = O) -N (R8) 2, - OR8, -O- (C> = O) -OR8, -O- (C> = O) -N (R8) 2, -NO2, -N (R8) 2, - ( NR8) -SO2-R8, -S (O) WR8, -SO2-N (R8) 2, (C1-C6), aryl (C6-C10) aryl, (C1-C9) heterocycloalkyl (C1-C9) and (C3-C10) wherein each of said (C1-C6), aryl (C6-C10) aryl, (C1-C9) heterocycloalkyl (C1-C9) alkyl or (C3-C10) group is optionally substituted independently with one, two, three or four R9 w is 0, 1 or 2 m is zero, one, two or three n is zero, one, two or three p is zero, one, two or three q is zero s is one t is one or a sot is one and the other of sot is two R3 is hydrogen or (C1-C6) each R4 is independently selected from hydrogen, or (C1-C6) wherein said (C1- C6) may be optionally substituted with one, two, three or four halogens, -CN, or -OR 9 or two R4 groups on the same carbon atom can be taken together to form an oxo radical (> = O) or spiro (C3-C6) R5 is hydrogen or (C1-C6) R6 is (C1-C5) -SO2- each R8 is independently selected from the group consisting of hydrogen, (C1-C6), aryl (C6-C10) aryl, (C1-C9) heterocycloalkyl (C1-C9) heteroaryl and (C3-C10) wherein said (C1-C6) can be optionally substituted with one, two or three substituents independently selected from hydrogen, halo, -CN, perfluoroalkyl (C1-C6), hydroxy, amino, (C1-C6), [ (C1-C6) alkyl] 2 amino, (C1-C6) perfluoroalkoxy, (C1-C6) alkyl, HO- (C> = O) -, (C1-C6) -O- (C> = O) -, formyl, (C1-C6) - (C> = O) -, H2N- (C> = O) -, alkyl (C1-C6) - (NH) - (C> = O) -, [(C1 C6 alkyl)] 2N- (C> = O) -, (C1-C6) - (C> = O) -O-, (H (C> = O) -NH-, (C1-C6) - (C> = O) -NH-, (C1-C6) - (C> = O) - [N ((C1-C6))] -, (C1-C6) -SO2- (C1 C6 alkyl) -SO2-NH-, (C1-C6) SO2- [N ((C1-C6))] -, H2N-SO2-, [(C1-C6)] - NH-SO2- and [(C1-C6) alkyl] 2N-SO2- wher
