The Governing Council of the University of Toronto
发明人:
GUNNING, Patrick Thomas,CUMARASWAMY, Abbarna A.,LEWIS, Andrew Martin,GELETU-HEYE, Mulu
申请号：
ES15800248
公开号：
ES2764279T3
申请日:
2015.05.29
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound of formula ** (See formula) ** where R1 is - (Ch2) n-aryl (C6-C10) or -C (= O) - (CH2) n-aryl (C6-C10), where aryl groups are optionally substituted with one to five substituents selected from halo, OH, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C4) alkyl substituted with halo, - (cyclopropyl) -CF3, - NO2, CN, -SO3R 'and -COOR', where R 'is H or (C1-C4) alkyl； R2 is - (CH2) n-aryl (C6-C10), where the aryl groups are substituted with one to five substituents selected from halo, OH, (C1-C6) alkyl, (C1-C6) alkoxy, alkyl ( C1-C4) substituted with halo, - (cyclopropyl) -CF3, -NO2, CN, -SO3R 'and -COOR', where R 'is H or (C1-C4) alkyl； R3 is - (CH2) n-aryl (C6-C10), wherein the aryl groups are optionally substituted with one to five substituents selected from halo, OH, (C1-C6) alkyl, (C1-C6) alkoxy, alkyl (C1-C4) substituted with halo, - (cyclopropyl) -CF3, -NO2, CN, -SO3R 'and -COOR', where R 'is H or (C1-C4) alkyl； X is -COOR ", -P (O) (OR") 2, tetrazole, -C (= O) NR "-OH or -CF2OH, where R" is H or (C1-C4) alkyl or -CH2- benzyl (C6-C10)； R4 and R5 are independently or simultaneously H or CF3, wherein one of R4 or R5 is H or, taken together R4 and R5 are -C (= O) or -C (= S)； R is H, OH, halo, (C1-C6) alkyl or (C1-C6) alkoxy； n is independently or simultaneously 0, 1, 2, 3, 4, 5 or 6 and m is 1, 2, 3 or 4； or a pharmaceutically acceptable salt, solvate and / or stereoisomer thereof.Un compuesto de fórmula **(Ver fórmula)** en donde R1 es -(Ch2)n-arilo (C6-C10) o -C(=O)-(CH2)n-arilo (C6-C10), en donde los grupos arilo están opcionalmente sustituidos con de uno a cinco sustituyentes seleccionados entre halo, OH, alquilo (C1-C6), alcoxi (C1-C6), alquilo (C1-C4) sustituido con halo, -(ciclopropil)-CF3, -NO2, CN, -SO3R' y -COOR', en donde R' es H o alquilo (C1-C4)； R2 es -(CH2)n-arilo (C6-C10), en donde los grupos arilo están sustituidos con de uno a cinco sustituyentes seleccionados entre halo, OH, alquilo (C1-C6), alcoxi (C1-C6), alquilo (C1-C4) sustituido con halo, -(c
