ARIKAWA, YASUYOSHI,JONES, BENJAMIN,LAM, BETTY,NIE, ZHE,SMITH, CHRISTOPHER,TAKAHASHI, MASASHI,DONG, QING,FEHER, VICTORIA
申请号：
PE0008852012
公开号：
PE01882013A1
申请日:
2010.12.17
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to pirrolidinona heteroaromaticos FUSED compounds of formula (i) where: G Is N and C (R5), L1 and L2 are independently NH and link R1 and R2 are independently h, alkyl, Halo, haloalquilo C1 - C3 and C1 - C3 or R1 and R2 with the Atom to which they are United cycloalkyl form C3 - C 6 R3 is C2 - C6 alkyl, cycloalkyl heteroaryl C1 - C3 - C8, C9, among others R4 is cycloalkyl C3, C8,Aryl heteroaryl C1 - C6 C1, C9, among others R5 is Halo, CN, h, among others. Are preferred compound: 2 - ((1R, 2S) - 2 - aminociclohexilamino) - 4 - (m-tolylamino) - 6.7 - dihydro - 5h pyrrolo [3,4-d] pyrimidine 5 - ona, 4 - (1H - indazol - 6 - ilamino) - 2 - ((1R, 2S) 2) - - - aminociclohexilamino 6,7 dihydro - 5h pyrrolo [3,4-d] pyrimidine 5 - ona, among others. Also referred to a Pharmaceutical composition.These compounds are inhibitors of the Spleen Tyrosine Kinase (SYK) to be useful for the treatment of allergic Asthma, multiple sclerosis, rheumatoid arthritis, psoriasisSE REFIERE A COMPUESTOS DE PIRROLIDINONA HETEROAROMATICOS FUSIONADOS DE FORMULA (I) DONDE: G ES N Y C(R5) L1 Y L2 SON INDEPENDIENTEMENTE NH Y UN ENLACE R1 Y R2 SON INDEPENDIENTEMENTE H, HALO, ALQUILO C1-C3 Y HALOALQUILO C1-C3, O R1 Y R2 JUNTO AL ATOMO AL CUAL ESTAN UNIDOS FORMAN CICLOALQUILO C3-C6 R3 ES ALQUILO C2-C6, CICLOALQUILO C3-C8, HETEROARILO C1-C9, ENTRE OTROS R4 ES CICLOALQUILO C3-C8, ARILO C6-C14, HETEROARILO C1-C9, ENTRE OTROS R5 ES HALO, CN, H, ENTRE OTROS. SON COMPUESTO PREFERIDOS: 2-((1R,2S)-2-AMINOCICLOHEXILAMINO)-4-(m-TOLILAMINO)-6,7-DIHIDRO-5H-PIRROLO[3,4-d]PIRIMIDIN-5-ONA, 4-(1H-INDAZOL-6-ILAMINO)-2-((1R,2S)-2-AMINOCICLOHEXILAMINO)-6,7-DIHIDRO-5H-PIRROLO[3,4-d]PIRIMIDIN-5-ONA, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA ESPLENICA (SYK) SIENDO UTILES PARA EL TRATAMIENTO DE ASMA ALERGICO, ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, SORIASIS
