A compound of formula (I), ** Formula ** including its physiologically acceptable salt, in which: Y is N or CR1； R1, is -H, halo or -C1-C4 alkyl； Z is -aryl, -C1-C8-alkyl, -C3-C8-cycloalkyl, C1-C6-alkyl, C6-cycloalkyl, heterocyclic, -C1-C8-alkylheterocyclic, X, is -H, -C1-C8-alkyl, -aryl, -C1 -alkyl -C8, -C3-C8-cycloalkyl, -C1-C8-alkyl C3-C8-cycloalkyl, heterocyclic, -C1-C8-heterocyclic alkyl, -NRiRj or -C1-C8-NRiRj alkyl； R2 and R3 are independently -H, -C1-C8 alkyl, -aryl, -C1-C8 alkyl, -C3-C8 cycloalkyl, -C1-C8 alkyl C3-C8 cycloalkyl, heterocyclic, -C1-C8 heterocyclic alkyl and -alkyl C1-C8-NRiRj, but R2 and R3 are not both H； Ri and Rj are independently -H or -C1-C8 alkyl； wherein heterocyclic is a 5-10 membered aromatic or saturated, cyclic or bicyclic cycloaliphatic-C1-C8 ring moiety containing 1, 2, or 3 heteroatoms selected from N, O or S； wherein aryl, -C3-C8 cycloalkyl and heterocyclic are optionally independently substituted with one to five substituents independently selected from -halo, -CN, -OH, -OCH2CH>； = CHCl, -C1-C6 alkyl, -O-C1-alkyl -C6 or -S-C1-C6 alkyl； and at each occurrence, the alkyl is optionally substituted with 1-5 halo, -CN or -OH.Un compuesto de fórmula (I),**Fórmula** incluyendo su sal fisiológicamente aceptable, en la que: Y es N o CR1； R1, es -H, halo o alquilo -C1-C4； Z es -arilo, -alquilarilo C1-C8, -cicloalquilo C3-C8, alquil C1-C6 cicloalquilo C6, heterocíclico, -alquilheterocíclico C1-C8, X, es -H, -alquilo C1-C8, -arilo, -alquilarilo C1-C8, -cicloalquilo C3-C8, -alquilo C1-C8 cicloalquilo C3-C8, heterocíclico, -alquilo C1-C8 heterocíclico, -NRiRj o -alquil C1-C8-NRiRj； R2 y R3 son independientemente -H, -alquilo C1-C8, -arilo, -alquilarilo C1-C8, -cicloalquilo C3-C8, -alquilo C1-C8 cicloalquilo C3-C8, heterocíclico, -alquilo C1-C8 heterocíclico y -alquilo C1-C8-NRiRj, pero R2 y R3 no son ambos H； Ri y Rj son independientemente -H o -alquilo C1-C8； en donde heterocíclico es un resto del anillo cicloalifático -C1-C8 aromático o
