The present invention is to extract the rice bran with hot water, filter the insoluble matter, and then treat the filtrate with glucoamylase and decompose the starch to obtain the water-soluble polysaccharide extract； add ammonium sulfate to the cultivated basidiomycete Lentinula edodes Culture the filtrate, and obtain the enzyme complex from its precipitate； add the water-soluble polysaccharide extract and the enzyme complex together, make it react at pH 4.5 for 30 to 60 minutes, and then make it at pH 6. React for 30-60 minutes at 0 to obtain a product that has been biologically modified to the water-soluble polysaccharide extract, and then the product is sterilized, sterilized, and concentrated for ingestion as a weakening improving food.本發明是將米糠以熱水萃取、過濾不溶物，再將此濾液以葡萄糖澱粉酶處理並分解澱粉而獲得水溶性多醣體萃取液；將硫酸銨添加至已培養擔子菌類香菇(Lentinula edodes)之培養濾液中，並自其沉澱物獲得酵素複合體；將該水溶性多醣體萃取液與該酵素複合體加在一起，使其在pH4.5下反應30~60分，再使其在pH6.0下反應30~60分，藉此獲得已對水溶性多醣體萃取液施加生物學上的修飾之生成物質，再將該生成物質例如進行除菌、滅菌並濃縮以作為虛弱改善食品來攝取。
