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Hat inhibitor of p300 / CBP and its application
专利权人:
CONSTELLATION PHARMACEUTICALS INC.
发明人:
LEVELL, JULIAN R.,BRUCELLE, FRANCOIS,WILSON, JONATHAN E.
申请号:
ARP190100378
公开号:
AR114256A1
申请日:
2019.02.15
申请国别(地区):
AR
年份:
2020
代理人:
摘要:
Formula compound (1),There are also pharmaceutically acceptable salts and compounds containing these substances that can be used to treat various conditions associated with acetyltransferase (ATT). 1. Claim 1: a compound with formula characteristics (1),Or a pharmaceutically acceptable salt in which the ring B is arilo, isopropene or isopropene, each of which is selectively replaced by one to four groups selected from r74955;R8310a is hydrogen or c833213183328326263; tar; r8311a is arilo or heterosexual, replaced by a group selected from r758484;Moreover, in r831111, these arilo and heterosexual can also be replaced by one or four groups selected from r74919;O r8310a and r8311a, together with their attached nitrogen atoms, form a bicyclic heteromorphism which can be selectively replaced by 1 to 4 groups selected from r7491;R1 es c83217c83318326; rental, c8383318326263; halotar, c8328331318326; - alquenilo-c8321i83318326;; alchemy 758080;-C832138318326263;Acquiln(R74966)8322;-C832135318326286;-Oquilc(o)Or74966;-C833218331-8326; - Asphalt (r74966) 832226;-C8321 8331 ° 8326; - asphalt 74966;-They are c833218331 / 8326281; asphalt (o) 8322278; r74966;-C832135318326263;Acquilson(R74966)8322;-C8321 8331 ° - 8326283 °; asphalt 8322; (r74966) 8322;-C832183318331838326; - c832183318326; - c832183318326; - c8321218338326; - ogitro-c832183318326; - okiterol-c83183318326;; lease, cyclochlorine, ash, isoiso or isocyclic tin, each of which is a-218321212183838326; - c2183212183;; A. let (c83218326); rent (c83218331832683); quilheteroarilo; and -One to three populations selected from r758080 replaced asphalt;Every one of them,R3,R830808,e. And r83099a are independent hydrogen or c832183318326263; tar can be replaced by one or two groups selected from halo-c (o) or74966;-The results showed that: oc.83218331 and 8326263; acquiln (r74969) 8322;-C832138318326263;Acquiln(R74966)8322;-N(R74966)8322;-7496; - c832183318326; - lease No. 74966;-Sor74966,-S(o)83222;(R74966,-It's (r74966) 832
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