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FUSED Heterocyclic compounds as ion Channel Modulators
专利权人:
GILEAD SCIENCES; INC.
发明人:
申请号:
ARP120102370
公开号:
AR086828A1
申请日:
2012.06.29
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. The compounds described in this specification are sodium channel inhibitors for the treatment of various diseases, including cardiovascular diseases and diabetes. 1. Claim 1: a formula compound (1),Cy was arilo, cycloquilo, heatcycle, cycloquine, cycloquine, O heterosexual; Q was covalent-o-quileno c8332083331;-Nr.1 - lessor c8320331;Lease No. c832221. Alquenileno c832220 or c83222 asphalt;M is 0, 1, 2 or 3; n is 0, 1, 2, 3, 4 or 5; each r183044 is selected independently from the halo group, - no.8322;-CN-SF832525,-Yes (ch832323) 8323;-O-R830404,-S-R830404,-C (O) -R-C (O) -OR-N (R) (R)-C (O) -N (R) (R)-N (R) -C (O) -R-N (R) -C (O) -OR-N (R) -S (O) -R-S (O) -R-O-S (O) -R-S (O) -N (R) (R)1. Lease land No. c833218331 and 832626;Alquenilo C83228331832424;1. C 83228331 asphalt;1. Cyclopentyl propyl, arillo, isopropyl and isopropyl, among which asphalt c83321316262;Alquenilo C83228331832424;1. C 83228331 asphalt;1. One, two or three substitutes independent of halogen-n ° 832222 can be selected to replace cyclopropyl, cyclopropyl, isopropyl or non cyclopropyl;Arilo, heterosexual, heterosexual, acquilo c832131;Halogenated tar c83218323;Bicycle, n (830404) (R2),-C (O) -R-C (O) -OR-C (O) -N (R) (R)-CN-Y-O-R830404;R2 es asphalt c8321131; 832626-r83099;-L-R83099;-L-tar compound c8321c833183226-r83099;-C83218c833126-l-r83099 or c83218831832626-l-acquileno c83331-r832609;I am what I am.- yes.-C (O) --NHS (O) --S(O)8322NH---C (O) NH- o -NHC (O) -2. When RZ is - l-r83090, o-l-tar layer c832183316263-r83099;So he's not - O- yes.-NHS (O) - o -NHC (O) -Each cubic meter is an independent hydrogen, deuterium, tar c833218331832626;1. C833218331832626 tar can be selectively replaced by one, two or three substitutes independent of halogen group;1. Cyclopentanediol, arilo, isopropene, isopropene, isopropene, n (km2);-C (O) -R-C (O) -OR-C (O) -N (R) (R)-CN-Y-O-R830404;1. Among the non halogenated-0.8322 substitutes, 1, 2 or 3 non halogenated-1, 2 or 3 substitutes can be selected to replac
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