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Substituted xanthines and their use in the treatment of a disorder mediated by TRPC5
- 专利权人:
- HYDRA BIOSCIENCES; INC.
- 发明人:
- BERTRAND CHENARD,SPENCER DAVIS KIMBALL,RANDAN GALLASCHUN
- 申请号：
- ARP140101183
- 公开号：
- AR095561A1
- 申请日:
- 2014.03.17
- 申请国别(地区):
- AR
- 年份:
- 2015
- 代理人:
- 摘要：
- Compounds, compositions and methods for inhibiting the TRPC5 ion channel and TRPC5 related disorders are described. Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof, wherein: R¹ is C₁₋₆ alkyl,a. Alquenilo c832283316a or acquinio c832283316a；Each of the alternatives is 1-4 cubic meters；R2 is lease No. c83217c831832626,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl,halo hidroxilo alcoxi C3. Heterosexual c83218c31832626；ariloxi C₆₋₁₀,arilalcoxi C₇₋₁₆,amino, C₁₋₆ alkylamino,dialquilamino C₂₋₁₂,-C (O) -- yes.-S-C₁₋₆ alkyl,-S (O) --S (O) -- that is...3. Isocyclopropyl, heteromorphic, sulfuryl, amide, urea, sulfur, acid, nitric acid, cyanogen, each of which is c832131；C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl,C₁₋₆ alkoxy,3. Heterosexual c83218c31832626；ariloxi C₆₋₁₀,arilalcoxi C₇₋₁₆,amino, C₁₋₆ alkylamino,dialquilamino C₂₋₁₂,- yes.-S-C₁₋₆ alkyl,-S (O) --S (O) -1-3r 3 m3 can be used instead of isocyclopropyl, heteromorphic, sulfuryl, amide, urea and flutamide；each R³ is independently C alquilo alkyl,3. Heterosexual c83218c31832626；hello, hello coxi C₁₋₆,Hydroxy, alcoxi c83216c833126；amino, C₁₋₆ alkylamino,dialquilamino C₂₋₁₂,Cyanogen, nitric acid, acyl ammonia, S-S (O) --C (O) --C (O) O-C₁₋₆ alkyl,-C (O) -alquilo CC₃₋₇ cycloalkyl,heterocycloalkyl, phenyl, or naphthyl, wherein each C₁₋₆ alkyl,3. Heterosexual c83218c31832626；hello Coxi C₁₋₆,C₁₋₆ alkoxy,amino, C₁₋₆ alkylamino,dialquilamino C₂₋₁₂,Amido, S...-S (O) --C (O) --C (O) O-C₁₋₆ alkyl,-C (O) -alquilo CC₃₋₇ cycloalkyl,e. Non cyclopentanediol, phenyl or n-propyl ethanol can be replaced by 1-3r830808；and each R⁴ is independently C alquilo alkyl,3. Heterosexual c83218c31832626；C₂₋₆ alkenyl,1. C 83228331 asphalt；C₃₋₇ cycloalkyl,hello Coxi C₁₋₆,C₁₋₆ haloalkyl,heterocycloalkyl, C₆₋₁₀ aryl,a. Heteromorphic, cycloclas c832318321； (8320；heterocycloalkylalkyl, C₇₋₁₆ arylalkyl,3. Infidels c83217c831832626；halo hidroxilo alcoxi CC₁₋₆ hydroxyalkyl,ariloxi C₆₋₁₀,arilalcoxi C₇₋₁₆,C₂₋₈ alko
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
