GRAY, JOHN DIXON,葛瑞 约翰 迪森,葛瑞 約翰 迪森,ZHOU, HEYUE,周贺钺,周賀鉞
申请号：
TW105104408
公开号：
TW201636369A
申请日:
2016.02.15
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
There is disclosed compositions and methods relating to or derived from anti-CTLA4 antibodies. More specifically, there is disclosed fully human antibodies that bind CTLA4, CTLA4-antibody binding fragments and derivatives of such antibodies, and CTLA4-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease requiring either stimulation of immune responses or suppression. Stimulation is achieved using antibodies that block binding of human CTLA4 to human B7 and diseases amenable to treatment by stimulation and augmentation of prolonging of immune responses include cancers of the prostate, kidney, colon, lung or breast pathogenic infections diseases associated with the CNS e.g. amyloidogenic diseases including Alzheimers disease and diseases with inflammatory or allergic components. Diseases amenable to treatment include graft versus host disease, host versus graft disease, allergy, autoimmune diseases and other inflammatory diseases.本發明揭示與抗CTLA4抗體相關或來源於抗CTLA4抗體之組合物及方法。更具體而言,本發明揭示結合CTLA4之全人類抗體、CTLA4-抗體結合片段及該等抗體之衍生物,及包含該等片段之CTLA4結合多肽。另外,本發明揭示編碼該等抗體、抗體片段及衍生物及多肽之核酸;包含該等聚核苷酸之細胞;製備該等抗體、抗體片段及衍生物及多肽之方法;及使用該等抗體、抗體片段及衍生物及多肽之方法,包括需要以刺激免疫反應或免疫抑制治療疾病之方法。刺激係使用阻斷人類CTLA4結合至人類B7之抗體實現,且適合藉由刺激及增強免疫反應之延長來治療之疾病包括前列腺癌、腎癌、結腸癌、肺癌或乳癌;病原感染;與CNS相關之疾病,例如生成性澱粉樣疾病,包括阿茲海默氏病(Alzheimers disease);及具有發炎或過敏組分之疾病。適合治療之疾病包括移植物抗宿主疾病、宿主抗移植物疾病、過敏、自體免疫疾病及其他發炎疾病。
