SWANSON, BARBARA A.,史旺森 芭芭拉Ａ,GRAY, JOHN DIXON,葛瑞 约翰 迪森,葛瑞 約翰 迪森,ZHOU, HEYUE,周贺钺,周賀鉞,史旺森 芭芭拉A,葛瑞 约翰 迪森,葛瑞 約翰 迪森
申请号：
TW105106782
公开号：
TW201639889A
申请日:
2016.03.04
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
There is disclosed compositions and methods relating to or derived from anti-CD47 antibodies. More specifically, there is disclosed fully human antibodies that bind CD47, CD47-antibody binding fragments and derivatives of such antibodies, and CD47-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.本發明揭示關於或衍生自抗CD47抗體之組合物及方法。更特定而言，本發明係揭示結合CD47之完全人類抗體、該等抗體之CD47-抗體結合片段及衍生物，及包含該等片段之CD47結合多肽。此外，本發明揭示編碼該等抗體、抗體片段及衍生物及多肽之核酸、包含該等多核苷酸之細胞、製備該等抗體、抗體片段及衍生物及多肽之方法及使用該等抗體、抗體片段及衍生物及多肽之方法(包括治療疾病之方法)。
