There is disclosed compositions and methods relating to or derived from anti-CD137 antibodies. More specifically, there is disclosed fully human antibodies that bind CD137, CD137-antibody binding fragments and derivatives of such antibodies, and CD137-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease requiring either stimulation of immune responses or suppression. Diseases amenable to treatment is selected from the group consisting of cancers, autoimmune diseases and viral infections.本發明揭示關於抗CD137抗體或自抗CD137抗體衍生之組合物及方法。更特定地，本發明揭示結合CD137之完全人類抗體；CD137抗體結合片段及此抗體之衍生物；及包含此片段之CD137結合多肽。此外，本發明揭示編碼此抗體、抗體片段及衍生物及多肽之核酸；包含此多核苷酸之細胞；製造此抗體、抗體片段及衍生物及多肽之方法；及使用此抗體、抗體片段及衍生物及多肽之方法，包括治療需刺激或抑制免疫反應之疾病之方法。可治療之疾病係選自由癌症、自體免疫疾病及病毒感染組成之群。
