There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that bind CD38, CD38-antibody binding fragments and derivatives of such antibodies, and CD38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.本發明揭示與抗CD38抗體相關或源於抗CD38抗體之組合物及方法。更特定言之，本發明揭示結合CD38之完全人類抗體、此類抗體之CD38抗體結合片段及衍生物以及包含此類片段之CD38結合多肽。另外，本發明揭示編碼此類抗體、抗體片段及衍生物以及多肽之核酸，包含此類聚核苷酸之細胞，製造此類抗體、抗體片段及衍生物以及多肽之方法，以及使用此類抗體、抗體片段及衍生物以及多肽之方法，包括治療疾病之方法。
