Boghaert, Erwin R.,Ackler, Scott L.,Tao, Zhi-Fu,Wang, Xilu,Doherty, George,Marin, Violeta L.,Sullivan, Gerard M.,Song, Xiaohong,Kunzer, Aaron R.,Welch, Dennie S.,Bruncko, Milan,Judd, Andrew S.,Souers,
申请号：
AU2015360609
公开号：
AU2015360609A1
申请日:
2015.12.09
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
