Tao, Zhi-Fu,Doherty, George,Wang, Xilu,Sullivan, Gerard M.,Song, Xiaohong,Kunzer, Aaron R.,Wendt, Michael D.,Frey, Robin R.,Cullen, Steve C.,Welch, Dennie S.,Shen, Xiaoqiang,Bennett, Nathan B.,Haight,
申请号：
AU2015360621
公开号：
AU2015360621A1
申请日:
2015.12.09
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Small molecule Bcl-xL inhibitorsand Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
