Scott L. Ackler,Erwin R. Boghaert,Milan Bruncko,George Doherty,Andrew S. Judd,Aaron R. Kunzer,Violeta L. Marin,Xiaohong Song,Andrew J. Souers,Gerard M. Sullivan,Zhi-fu Tao,Xilu Wang,Dennle S. Welch
申请号：
US16412729
公开号：
US20200246323A1
申请日:
2019.05.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
