Andrew J. Souers;Scott L. Ackler;George Doherty;Steve C. Cullen;Gerard M;Erwin R. Boghaert;Anthony R. Haight;Nathan B. Bennett;Xiaoqiang Shen;Andrew S. Judd;Xiaohong Song;Aaron R. Kunzer;Robin R. Frey
发明人:
Scott L. Ackler,Nathan B. Bennett,Erwin R. Boghaert,Steve C. Cullen,George Doherty,Robin R. Frey,Anthony R. Haight,Andrew S. Judd,Aaron R. Kunzer,Xiaoqiang Shen,Xiaohong Song,Andrew J. Souers,Gerard M
申请号：
US14963510
公开号：
US20160158377A1
申请日:
2015.12.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
