TAO, ZHI-FU,DOHERTY, GEORGE,WANG, XILU,SULLIVAN, GERARD M.,SONG, XIAOHONG,KUNZER, AARON R.,WENDT, MICHAEL D.,FREY, ROBIN R.,CULLEN, STEVE C.,WELCH, DENNIE S.,SHEN, XIAOQIANG,BENNETT, NATHAN B.,HAIGHT,
申请号：
CA2970161
公开号：
CA2970161A1
申请日:
2015.12.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Small molecule Bcl-xL inhibitorsand Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
