SAUS, JUAN,FUSTERO, SANTOS,SANZ-CERVERA, F. JUAN,PEREZ-PAYA, ENRIQUE,BLASCO, RAÜL,REVERT-ROS, FRANCISCO,REVERT, FERNANDO
申请号：
ES10779469
公开号：
ES2523118T3
申请日:
2010.11.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R is selected from N and CR5； R5 is selected from the group consisting of hydrogen, halogen, cyano, nitro, hydroxy, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, halo (alkyl 1 to 6 carbon atoms), alkoxy of 1 to 6 carbon atoms, halo (alkoxy of 1 to 6 carbon atoms), amino, (alkyl of 1 to 6 carbon atoms) amino, di (alkyl of 1 to 6 6 carbon atoms) amino, hydroxy (alkyl of 1 to 6 carbon atoms), (alkoxy of 1 to 6 carbon atoms) alkyl of 1 to 6 carbon atoms, amino (alkyl of 1 to 6 carbon atoms), sulfanyl (alkyl of 1 to 6 carbon atoms), (alkyl of 1 to 6 carbon atoms) sulfanil (alkyl of 1 to 6 carbon atoms), - (CH2) 1-5-C (O) (alkoxy of 1 at 6 carbon atoms), - (CH2) 1-5-C (O) NH2, (aryl) alkyl of 1 to 6 carbon atoms, and (heteroaryl) alkyl of 1 to 6 carbon atoms； R1 is hydrogen, halogen, hydroxy, alkyl of 1 to 6 carbon atoms, halo (alkyl of 1 to 6 carbon atoms), alkoxy of 1 to 6 carbon atoms, halo (alkoxy of 1 to 6 carbon atoms), hydroxy (alkyl of 1 to 6 carbon atoms), (alkoxy of 1 to 6 carbon atoms) alkyl of 1 to 6 carbon atoms, amino (alkyl of 1 to 6 carbon atoms), sulfanyl (alkyl of 1 to 6 carbon atoms), or (alkyl of 1 to 6 carbon atoms) sulfanyl (alkyl of 1 to 6 carbon atoms)； R2 is alkyl of 1 to 6 carbon atoms, halo (alkyl of 1 to 6 carbon atoms), alkoxy of 1 to 6 carbon atoms, halo (alkoxy of 1 to 6 carbon atoms), hydroxy (alkyl of 1 to 6 6 carbon atoms), (alkoxy of 1 to 6 carbon atoms) alkyl of 1 to 6 carbon atoms, formyl (alkyl of 1 to 6 carbon atoms), amino (alkyl of 1 to 6 carbon atoms), sulfanyl (alkyl of 1 to 6 carbon atoms), (alkyl of 1 to 6 carbon atoms) sulfanyl (alkyl of 1 to 6 carbon atoms), - (CH2) 1-5-C (O) OH, - (CH2 ) 1-5-C (O) (alkoxy of 1 to 6 carbon atoms), - (CH2) 1-5-C (O) NH2, (aryl) alkyl of 1 to 6 carbon atoms, or (heteroaryl) alkyl of 1 to 6 carbon atoms； R3 is alkyl of 1 to 6 carbon atoms, halo (alkyl of 1
