BELLENIE, Benjamin Richard,BRUCE, Ian,CULSHAW, Andrew James,HOLLINGWORTH, Gregory,NEEF, James,SPENDIFF, Matthew,WATSON, Simon James
申请号：
ES14726416
公开号：
ES2667424T3
申请日:
2014.04.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula (I): ** Formula ** wherein: E is selected from N and CRE； R1, R2 and RE are independently selected from H, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halo-alkyl of 1 to 4 carbon atoms, halo-alkoxy of 1 to 4 carbon atoms, and cycloalkyl of 3 to 6 carbon atoms； R3 is selected from: (i) alkyl of 1 to 4 carbon atoms that is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxyl, hydroxy-alkyl of 1 to 4 carbon atoms, halogen, halo- alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, oxo, -NR3aR3b and cycloalkyl of 3 to 6 carbon atoms, and wherein the cycloalkyl of 3 to 6 Carbon atoms are unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxyl, hydroxy-alkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, and halo-alkyl of 1 to 4 atoms carbon； (ii) alkoxy of 1 to 4 carbon atoms that is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxyl, hydroxy-alkyl of 1 to 4 carbon atoms, halogen, halo-alkyl of 1 to 4 atoms of carbon, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, oxo, -NR3aR3b and cycloalkyl of 3 to 6 carbon atoms, and wherein the cycloalkyl of 3 to 6 carbon atoms is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxyl, hydroxy-alkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, and halo-alkyl of 1 to 4 carbon atoms； (iii) -cycloalkyl of 3 to 6 carbon atoms or -O-cycloalkyl of 3 to 6 carbon atoms, wherein the cycloalkyl of 3 to 6 carbon atoms is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxyl, hydroxy-alkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, halo-alkyl of 1 to 4 carbon atoms, and - (alkyl of 0 to 3 carbon atoms) -NR3aR3b； (iv) - (alkyl of 0 to 3 carbon atoms) -cycloalkyl of 3 to 6 carbon atoms or - (O-alkyl of 0 to
