The present invention provides an antigen-binding molecule that exhibits an excellent antitumor effect greater than exhibited by conventional antigen-binding molecules, as a result of the antigen-binding molecule: cross-linking T cells and cells having an immune response suppressing function； and inducing damage to the cells having the immune response suppressing function. The antigen-binding molecule includes: a domain (1) that binds to molecules expressed on the surface of cells having the immune response suppressing function； and a domain (2) that binds to a T cell receptor complex.本發明發現包含(1)結合於在具有抑制免疫反應之機能之細胞之表面表現之分子之分域、及(2)結合於T細胞受體複合體之分域之抗原結合分子，會將具有抑制免疫反應之機能之細胞與T細胞交聯而誘導具有抑制免疫反應之機能之細胞之傷害，藉此比起習知抗原結合分子發揮更優良之抗腫瘤效果。
