T cell-redirected antigen-binding molecule for cells having immunosuppression function

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专利权人:

Chugai Seiyaku Kabushiki Kaisha;Osaka University

发明人:

Igawa, Tomoyuki,Ishiguro, Takahiro,Sakaguchi, Shimon,Nishikawa, Hiroyoshi

申请号：

AU2015260230

公开号：

AU2015260230A1

申请日:

2015.05.13

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention provides an antigen-binding molecule that exhibits an excellent antitumor effect greater than exhibited by conventional antigen-binding molecules, as a result of the antigen-binding molecule: cross-linking T cells and cells having an immune response suppressing function； and inducing damage to the cells having the immune response suppressing function. The antigen-binding molecule includes: a domain (1) that binds to molecules expressed on the surface of cells having the immune response suppressing function； and a domain (2) that binds to a T cell receptor complex.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/