T CELL-REDIRECTED ANTIGEN-BINDING MOLECULE FOR CELLS HAVING IMMUNOSUPPRESSION FUNCTION

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA;OSAKA UNIVERSITY

发明人:

IGAWA, TOMOYUKI,ISHIGURO, TAKAHIRO,SAKAGUCHI, SHIMON,NISHIKAWA, HIROYOSHI

申请号：

SG11201609370Q

公开号：

SG11201609370QA

申请日:

2015.05.13

申请国别(地区):

SG

年份:

2016

代理人:

摘要：

It was discovered that antigen-binding molecules comprising (i) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions, and (ii) a T cell receptor complex-binding domain exhibit more superior antitumor effects than conventional antigen-binding molecules by crosslinking T cells with cells having immune response-suppressing functions, and damaging the cells having immune response-suppressing functions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/