MOLÉCULE DE LIAISON À UN ANTIGÈNE QUI REDIRIGE UN LYMPHOCYTE T VERS CELLULES PRÉSENTANT UNE FONCTION D'IMMUNOSUPPRESSION

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专利权人:

Chugai Seiyaku Kabushiki Kaisha;Osaka University

发明人:

IGAWA, Tomoyuki,ISHIGURO, Takahiro,SAKAGUCHI, Shimon,NISHIKAWA, Hiroyoshi

申请号：

EP15793048

公开号：

EP3144388B1

申请日:

2015.05.13

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

It was discovered that antigen-binding molecules comprising (i) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions, and (ii) a T cell receptor complex-binding domain exhibit more superior antitumor effects than conventional antigen-binding molecules by crosslinking T cells with cells having immune response-suppressing functions, and damaging the cells having immune response-suppressing functions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/