BANCEL, Stephane,SCHRUM, Jason P.,EJEBE, Kenechi,ELLSWORTH, Jeff Lynn,GUILD, Justin,CHAKRABORTY, Tirtha,DE FOUGEROLLES, Antonin,ELBASHIR, Sayda M.,JOHN, Matthias,ROY, Atanu,WHORISKEY, Susan,WOOD, Kris
申请号：
USUS2013/030070
公开号：
WO2013/151672A3
申请日:
2013.03.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. The present invention provides an isolated polynucleotide comprising a first region of linked nucleosides, said first region encoding the oncology-related polypeptide of interest, a first flanking region Iocated at the 5' terminus of said first region comprising a sequence of linked nucleosides selected from the group consisting of the native 5' untranslated region (UTR) of any of SEQ ID NOs: 4704-9203, SEQ ID NOs: 1-4 and functional variants thereof and a second flanking region Iocated at the 3' terminus of said first region comprising a sequence of linked nucleosides selected from the group consisting of the native 3' UTR of any of SEQ ID NOs: 4704-9203, SEQ ID NOs: 5-21 and functional variants thereof and a 3' tailing sequence of linked nucleosides.L'invention concerne des compositions et des procédés de préparation, de fabrication et d'utilisation thérapeutique de polynucléotides associés à l'oncologie, de transcrits primaires associés à l'oncologie et de molécules d'ARNm modifiées associées à l'oncologie.
