Bancel, Stephane,De Fougerolles, Antonin,Ejebe, Kenechi,Chakraborty, Tirtha,Elbashir, Sayda M.,John, Matthias,Roy, Atanu,Whoriskey, Susan,Wood, Kristy M.,Hatala, Paul,Schrum, Jason P.,Ellsworth, Jeff
申请号：
AU2018200377
公开号：
AU2018200377A1
申请日:
2018.01.19
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018200377A120180322.pdf#####ABSTRACT The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. The present invention provides an isolated polynucleotide comprising a first region of linked nucleosides, said first region encoding the oncology-related polypeptide of interest, a first flanking region located at the 5' terminus of said first region comprising a sequence of linked nucleosides selected from the group consisting of the native 5' untranslated region (UTR) of any of SEQ ID NOs: 4704-9203, SEQ ID NOs: 1-4 and functional variants thereof and a second flanking region located at the 3' terminus of said first region comprising a sequence of linked nucleosides selected from the group consisting of the native 3' UTR of any of SEQ ID NOs: 4704-9203, SEQ ID NOs: 5-21 and functional variants thereof and a 3' tailing sequence of linked nucleosides.
