PROBLEM TO BE SOLVED: To provide a compound based on a nucleic acid encoding a cosmetic polypeptide or a cosmetic polynucleotide.SOLUTION: There is provided a method of treating a disease, disorder, and/or condition in a subject in need of treating a disease, disorder, and/or condition by increasing a level of a polypeptide described below. A cosmetic polypeptide comprises an isolated polynucleotide comprising: (a) a first region of linked nucleoside, the first region encoding a cosmetic polypeptide selected from specific sequences； (b) a first flanking region located at the 5' terminus of the first region, the first flanking region comprising a sequence of linked nucleoside selected from the group of specific sequences and the native 5' untranslated region (UTR) in any of their related coding nucleic acids； and (c) a second flanking region located at the 3' terminus of the first region, the second flanking region comprising a sequence of linked nucleoside selected form the group of specific sequences and the native 3' UTR in any of their related coding nucleic acids and a 3' tailing sequence of linked nucleoside.SELECTED DRAWING: None【課題】美容ポリペプチドをコードする核酸系化合物又は美容ポリヌクレオチドの提供。【解決手段】下記のポリペプチドの量を増やすことにより、疾患、障害及び／又は状態の治療を必要とする対象において疾患、障害及び／又は状態を治療する方法。（ａ）結合ヌクレオシドの第一の領域で、特定の配列から選択される美容ポリペプチドをコードする、第一の領域と、（ｂ）前記第１の領域の５’末端に位置する第１の隣接領域で、特定配列群及にそれらの関連コードする核酸の内の天然５’非翻訳領域（ＵＴＲ）から選択される結合ヌクレオシドの配列を含む第一の隣接領域と、（ｃ）前記第１の領域の３’末端に位置する第２の隣接領域で、特定配列群及びそれらの関連コードする核酸の内の天然３’ＵＴＲから選択される結合ヌクレオシド配列と、結合ヌクレオシドの３’尾部配列と、を含む、第２隣接領域とを含む単離ヌクレオジを含む、美容ポリペチド【選択図】なし
