PROCESS FOR fluorinating anilide derivatives AND BENZOTHIAZOLFLUORINATDERIVATER AS IN VIVO IMAGING AGENTS

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专利权人:

GE HEALTHCARE LIMITED;GE HEALTHCARE AS

发明人:

JONES, CLARE, LOUISE,BOUVET, DENIS, RAYMOND, CHRISTOPHE,LASBISTES, NICOLAS,FAIRWAY, STEVEN, MICHAEL,WILLIAMS, LORENZO,GIBSON, ALEXANDER, MARK,NAIRNE, ROBERT, JAMES,KARIMI, FARHAD,LANGSTROM, BENGT,STOR

申请号：

DK06765263

公开号：

DK1915330T3

申请日:

2006.08.11

申请国别(地区):

DK

年份:

2015

代理人:

摘要：

The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl； which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, &mdash；(CH2CH2O)q&mdash；CH3 wherein q is an integer of from 1 to 10； R1 is as defined for the compound of formula (I)； and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

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