PROCÉDÉ DE FLUORATION DE DÉRIVÉS ANILIDE ET DÉRIVÉS BENZOTHIAZOLE FLUORÉS EN TANT QU'AGENTS D' IMAGERIE IN VIVO

• 收藏
• 分享

专利权人:

GE HEALTHCARE LIMITED;GE HEALTHCARE AS

发明人:

申请号：

EP06765263.6

公开号：

EP1915330B1

申请日:

2006.08.11

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl； which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, &mdash；(CH2CH2O)q&mdash；CH3 wherein q is an integer of from 1 to 10； R1 is as defined for the compound of formula (I)； and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/