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Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents
专利权人:
GE Healthcare Limited;GE Healthcare AS
发明人:
Langstrom, Bengt,Karimi, Farhad,Lasbistes, Nicolas,Storey, Anthony Eamon,Nairne, Robert James,Gibson, Alexander Mark,Fairway, Steven Michael,Bouvet, Denis Raymond Christophe,Jones, Clare Louise,Willia
申请号:
AU2006281216
公开号:
AU2006281216B2
申请日:
2006.08.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to a process for preparation of a compound of formula (I):R is selected from Calkyl, Calkenyl,and Calkynyl ; which comprises: (i) reaction with fluoride, suitably[F]fluoride, of a corresponding compound of formula (II): whereinR is selected from hydrogen, Calkyl, Chaloalkyl,Caryl,Carylalkyl, -(CHCHO)-CHwherein q is an integer of from 1 to 10; R is as defined for the compoundof formula (I); and R is a leaving group. Certain novel precursorsof formula (II) and radiopharmaceutical kits containing such precursors arealso claimed.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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