Anthony Eamon Storey,Clare Louise Jones,Denis Raymond Christophe Bouvet,Nicolas Lasbistes,Steven Michael Fairway,Lorenzo Williams,Alexander Mark Gibson,Robert James Nairne,Farhad Karimi,Bengt Langstro
申请号：
US14809497
公开号：
US09468694B2
申请日:
2015.07.27
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to a process for preparation of a compound of formula (I):R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl；which comprises:(i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II):wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10；R1 is as defined for the compound of formula (I)； andR3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
