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Derivatives of 7- (heteroaryl-amino) -6,7,8,9-tetrahydropyridido [1,2-a] indole acetic acid and its use as modulators of the prostaglandin D2 receptor
专利权人:
Actelion Pharmaceuticals Ltd.
发明人:
AISSAOUI, Hamed,BOSS, Christoph,GABILLET, Jerome,RICHARD-BILDSTEIN, Sylvia,SIEGRIST, Romain
申请号:
ES12722194
公开号:
ES2596581T3
申请日:
2012.04.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I): ** Formula ** in which R1 and R2 independently represent each other hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, halogen, trifluoromethoxy or trifluoromethyl; R3 represents hydrogen, (C1-C4) alkyl, (C1-C2) alkoxy-(C2-C3) alkyl, (C1-C4) fluoroalkyl (C3-C6) cycloalkyl-(C1-C2) alkyl; and R4 represents a heteroaryl group that is unsubstituted or mono-, di- or tri-substituted, in which the substituents are independently selected from the group consisting of halogen, (C1-C4) alkyl, cycloalkyl (C3-C6), (C1-C4) alkoxy, (C1-C4) fluoroalkyl and phenyl; or a pharmaceutically acceptable salt of said compound.Un compuesto de fórmula (I): **Fórmula** en la que R1 y R2 representan independientemente entre sí hidrógeno, alquilo (C1-C4), alcoxi (C1-C4), halógeno, trifluorometoxi o trifluorometilo; R3 representa hidrógeno, alquilo (C1-C4), alcoxi (C1-C2)-alquilo (C2-C3), fluoroalquilo (C1-C4) o cicloalquil (C3-C6)- alquilo (C1-C2); y R4 representa un grupo heteroarilo que está no sustituido o mono-, di- o tri-sustituido, en el que los sustituyentes se seleccionan independientemente del grupo que consiste en halógeno, alquilo (C1-C4), cicloalquilo (C3-C6), alcoxi (C1-C4), fluoroalquilo (C1-C4) y fenilo; o una sal farmacéuticamente aceptable de dicho compuesto.
来源网站:
中国工程科技知识中心
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