TEEGARDEN, BRADLEY,CHAPMAN, DENNIS,CHOI, JUYI,FEICHTINGER, KONRAD,HAN, SANGDON,JAYAKUMAR, HONNAPPA,TRAN, THUY-ANH,XU, JINGDONG,ZOU, NING
申请号：
ES07777120
公开号：
ES2536762T3
申请日:
2007.05.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound selected from compounds of Formula (Ia) and pharmaceutically acceptable salts, hydrates, and solvates thereof: ** Formula ** in which: X is O or S； V is O or NH； W is C1-4 alkylene optionally substituted with 1,2, 3, 4, 5, 6, 7 or 8 substituents independently selected from C1-3 alkyl, C1-4 alkoxy, carboxy, cyano, C3-7 cycloalkyl, C1- haloalkyl 3, halogen, oxo and imino, wherein said C1-3 alkyl is optionally substituted with C1-3 alkylsulfonyl； Z is C1-4 alkylene optionally substituted with 1,2, 3, 4, 5, 6, 7 or 8 substituents independently selected from C1-3 alkyl, C1-4 alkoxy, carboxy, cyano, C1-3 haloalkyl, halogen and oxo ； or Z is absent； R1 is selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-7 cycloalkyl； R2 is selected from H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkylcarboxamide, C2-6 alkynyl, C1-6 alkylsulfonamide, C1-6 alkylsulfinyl , C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 alkylureyl, amino, C1-6 alkylamino, C2-8 dialkylamino, C1-6 carbo alkoxy, carboxamide, carboxy, cyano, C3-7 cycloalkyl, C2-8 dialkylcarboxamide , C2-8 dialkylsulfonamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl, C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, hydroxyl, thiol, nitro and sulfonamide； R 3 is selected from H, C 2-6 alkenyl, C 1-6 alkyl, C 1-6 alkylcarboxamide, C 2-6 alkynyl, C 1-6 alkylsulfonamide, C 1-6 carboxy alkoxy, carboxamide, carboxy, cyano, C 3-7 cycloalkyl, dialkylcarboxamide C2-8, halogen, heteroaryl and phenyl； and wherein each of the C2-6 alkenyl, C 1-6 alkyl, C 2-6 alkynyl, C 1-6 alkylsulfonamide, C 3-7 cycloalkyl, heteroaryl and phenyl groups is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-5 acyl, C1-5 acyloxy, C2-6 alkenyl, C1-4 alkoxy, C1-8 alkyl, C1-6 alkylamino, C2-8 dialkylamino, C1-4 alkylcarboxamide, C2-6 alkynyl, C 1-4 alkylsulfonamide, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, C 1-4 alkylthio, C 1-4 alkylureyl, amino, C 1-6 carboxy
