BAKER-GLENN CHARLES,BURDICK DANIEL JON,CHAMBERS MARK,CHAN BRYAN K.,CHEN HUIFEN,ESTRADA ANTHONY,SWEENEY ZACHARY KEVIN
申请号：
ARP110104181
公开号：
AR083813A1
申请日:
2011.11.09
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
The use of these compounds in the treatment of diseases related to lrk2 receptors, such as Parkinson's disease, claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, in which: X is: -NRa- or -O- where Ra is hydrogen or C1-6 alkyl； R1 is: C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl； halo C1-6 alkyl； C1-6 alkoxy-C1-6 alkyl； hydroxyC 1-6 alkyl； amino C1-6 alkyl； C1-6 alkylsulfonyl-C1-6 alkyl； C3-6 cycloalkyl, optionally substituted one or more times with C1-6 alkyl； C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl part is optionally substituted one or more times with C1-6 alkyl； heterocyclyl, optionally substituted one or more times with R7 or heterocyclyl-C1-6 alkyl, optionally substituted one or more times with R7； or X and R1 together form C1-6 alkyl；C1-6 alkoxy-C1-6 alkyl C3-6 cycloalkyl, optionally substituted one or more times with R6 or C3-6 cycloalkyl-C1-6 alkyl, where the C3-6 cycloalkyl part is optionally substituted one or more times with R6 ； or R1 and Ra together with the atoms to which they are attached can form a three to six membered heterocyclic ring, optionally substituted one or more times with R7； R2 is: C1-6 alkyl； halo； C1-6 alkoxy； cyano； C2-6 alkynyl； C2-6 alkenyl； halo C1-6 alkyl； C1-6 haloalkoxy； C3-6 cycloalkyl, optionally substituted one or more times with R6； C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl part is optionally substituted one or more times with R6；-ORb where Rb is C1-6 alkyl, C3-6 cycloalkyl, optionally substituted one or more times with R6, or C3-6 cycloalkyl-C1-6 alkyl, where the C3-6 cycloalkyl part is optionally substituted one or more times with R6 or -C (O) -Rc where Rc is C1-6 alkyl, C1-6 alkoxy, amino, or heterocyclyl, optionally substituted one or more times with R7； R3 is: hydrogen； C1-6 alkyl； halo C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl； hydroxyC 1-6 alkyl； C1-6 alkoxy-C1-6 alkyl； cyano-C1-6 alkyl； C1-6 alkylsulfonyl； C1-6 alkylsulfonyl-C1-6 alkyl； amino C1-6 alkyl； C3-6 cycloalky
