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Cxcr7 receiver modulators
专利权人:
Idorsia Pharmaceuticals Ltd
发明人:
FRETZ, Heinz,GUERRY, Philippe,KIMMERLIN, Thierry,LEHEMBRE, Francois,POTHIER, Julien,SIENDT, Hervé,VALDENAIRE, Anja
申请号:
ES14730591
公开号:
ES2645470T3
申请日:
2014.05.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I) ** Formula ** in which -presents NR5, and Y represents CHRY in which RY represents hydrogen, or (C1-3) alkyl; and -and R3b together with the carbon atom to which they are attached to form a carbonyl group, or -of R2a, R2b, R3a and R3b independently represent hydrogen, or (C1-3) alkyl; and the rest of R2a, R2b, R3a and R3b represent hydrogen; or - represents CHRX in which RX represents hydrogen, or (C1-3) alkyl, and Y represents NR5; and -and R2b together with the carbon atom to which they are attached to form a carbonyl group, or -of R2a, R2b, R3a and R3b independently represent hydrogen, or (C1-3) alkyl; and the rest of R2a, R2b, R3a and R3b represent hydrogen; or -present NR5 and Y represents a direct link; R2a and R2b both represent hydrogen; and R3a and R3b both represent hydrogen; or -presents NR5, Y represents -C (O) -; and R2a, R2b R3a and R3b all represent hydrogen; or -presents -C (O) -, Y represents NR5; and R2a, R2b R3a and R3b all represent hydrogen; R5 represents -yl (C1-6); -lo (C1-4) mono-substituted with (C1-3) alkoxy, cyano, vinyl; ethynyl, or (C1-3) alkoxycarbonyl; -R10 in which R10 represents (C1-5) alkyl; (C1-5) alkoxy; phenyl; phenyl-oxy; phenyl (C1-3) alkyl -; phenyl (C1-3) alkyl-oxy-; C3-6 cycloalkyl (C1-3) alkyl; alkenoxy (C3-4); (C3-4) alkyloxy; fluoroalkyl (C1-3); fluoroalkoxy (C1-3); (C1-3) alkoxy (C2-3) alkoxy; (C1-3) alkoxy-(C1-3) alkyl; C3-6 cycloalkyl optionally containing an oxygen atom in the ring, wherein said cycloalkyl is optionally mono- or di-substituted in which the substituents independently are fluorine or fluoroalkyl (C1); 5-membered unsubstituted heteroaryl; or -25 NR10aR10b in which R10a and R10b independently represent hydrogen, (C1-4) alkyl or cycloalkyl (C3-6), or R10a and R10b together with the nitrogen to which they are attached to form a saturated ring of 5 to 7 members ; --R11 in which R11 represents (C1-5) alkyl or phenyl; -alkyl (C2-4); -C3-6alkyl optionally containing an oxygen atom in t
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