IAKOVLEV, Pavel Andreevich,MINDICH, Aleksei Leonidovich,GORBUNOVA, Svetlana Leonidovna,POPKOVA, Aleksandra Vladimirovna,SHEKHAUTSOU, Artsiom Evgenievich,ALAFINOV, Andrei Ivanovich,ALESHUNIN, Pavel Ale
申请号：
CO2020001326
公开号：
CO2020001326A2
申请日:
2020.02.06
申请国别(地区):
CO
年份:
2020
代理人:
摘要：
Abstract: the invention refers to one: a new compound of formula one, or a salt or stereoisomer approved by its medicament, in which 1 represents n, C, H.[options 2, 3 and 4 represent C (H) m, NH, N, Cr13 and chr13 respectively； L1 and L2 represent chemical links respectively,]-Is-General service (other level)-C (male)-Well-C（=n19）-；N. K stands for 0, 1, 2； R1, R3, R13 stands for H, Hal, ciao, acqui c-c6, NH2； R2, R4 stands for an independent group, consisting of:-No. 11 R12； No. 1 - No. 6 asphalt, replaced or not replaced by one or more R14； No. X5, X6, X7 stand alone for C,Ch，N；L3，L，1，1，1，1，1，1——No.-CH2…-Well-C（1）-N7A，-C（=NH）-；P = 0, 1, 2, 3, 4； R5 stands for H； Hal； cyanogen； asphalt； asphalt-1-c； c11-c； c16-c； c16-c； c15r16； arilo, replace or not replace with one or more substitutes selected from Hal, C1-C6, c1xi-c, c11-c, n15r16； 5-6 isocyclic propene with 1-2 heteroatom component selected from N and / or is not replaced by one or more substitutes selected from Hal, c-1-c tar, c-1-c 6 tar, n15r16, R6, r6a,Each independent representative of R6b is h, Hal, hidroxi, C1-C6, c1xi C-C, c11-c, R7 and r7a,C1-C6； R8； R9 as a percentage of the United Nations.C-c1-c6-c-nr22-cn-c (o) - or20； or R8 and R9, plus the carbon atoms connected with them, form a 5-6 aperiodic ring composed of 1-2 heteroatoms, selected from oxygen and / or nitrogen, The ring containing R8 and R9 can be replaced or not replaced by one or two selected substitutes of oxo group, i.e. C1-C6 asphalt； each R10 is selected from a separate consortium,Hal, C16, hydroxy, cyanogen, c1xi C1-C6, c11-c1-c1-c1-c1-c1-6, c1xi-c1-6, c16-c1-6, c16-6, c16-c6, n23r24； 5-6 hetero compounds, including 1-2 heteroatoms selected from n, C and / or s 1. One or more c-1-c6, asphalt (o) 2-c-1-c6, R11 and R12 are not used to represent h, c-1-c6, c-c6, c-hydroxi, c-cyclo c-c6, c-23ar24a, c-1-c6, c-c6, c-1-c6, c-c3-c6 and R14 respectively represent HAL-C (United Nations Headquarters) No. 1718 and c-1-6；R15, R16, R19, R20, R21, R22
