IAKOVLEV, Pavel Andreevich,GORBUNOVA, Svetlana Leonidovna,MIKHAYLOV, Leonid Evgen´evich,MOLDAVSKY, Alexander,KUKUSHKINA, Anna Aleksandrovna,KUSHAKOVA, Anna Sergeevna,GAVRILOV. Aleksey Sergeevich,SILON
申请号：
CR20190261
公开号：
CR20190261A
申请日:
2017.11.16
申请国别(地区):
CR
年份:
2019
代理人:
摘要：
The invention refers to a new first-class compound: V2 V1 n R1 R6 r4r11 LR 3 N1 or a pharmaceutically acceptable solvent or salt, wherein: 5 V1 is C or N, V2 is C (R2) or N, therefore, if V1 is C, V2 is n, if V1 is C, V1 is C, V2 is C (R2),Or if V1 is n, V2 is C (R2)；Each n, K is an independent 0, 1； each R2, R11 is an independent h, D, Hal, CN, NR,C（O）NRR，C1-C6； R3 is h, D, hydroxi, C1 (o) C1-C6, alquenilo C (o) C2-C6, acquinilo C (o) C2-C6, acquilo C1-C6, acquilo C1-C6； R4 is h, Hal, CN, conrr,A5, A5, A5, A5, A5, A5, A5, a7 8 A9 is independent C, ch or N, R5 is h, CN, Hal, conrr,C1-C6 tar, not replaced or replaced by one or more halogens； each R and R is selected independently from the group containing H, C1-5 C6 tar, C1-C6 cyclohexane, arilo； R6 is selected from the group: n R7 orN O R8N O R9，N O R10；R7, R8, R9, R10 are monomers of ethylene and methyleneacetylene； Hal is Cl, Br, I, F, 10 with the properties of BTK quina thyroid inhibitor,A compositions of medical compositions which contained these compositions，and use to medical production of disease and disease.The present invention relates to a new compound of formula I：or pharmaceutically acceptable salt，solvate or stereoisomer thereof，wherein：v1 is c or n，v2 is c（r2）or n，where reby if v1 is c then V2 is n，if v1 is c then v2 is c（r2），Or if v1 is n them v2 is c（r2）；EACH N，K is independently 0，1；EACH R2，R11 is independently H，D，Hal，CN，NR'R”，C（o）nr'r，C1-C6 alcoxy；R3 is h，d，hydroxy，c（o）C1-C6 alkyl，c（o）C2-C6 alkenyl，c（o）C2-C6 alkynyl，C1-C6 alkyl；R4 is h，hal，cn，conr'r”，Hydroxy，C1-C6 alkyl，C1-C6 alkoxy；L is c h 2，NH，o o r chemical bond；R1 is selected from the group of the fragments，comprising:fragment 1，fragment 2，fragment 3 each A1，A2，A3，A4 is independently CH，A6，A7，A8，A9 is independently C，CH or N；R5 is H，Hal，Conr'r”，C1-C6 alkyl，non-substituted or substituted by one or more halogens；each R'and R“is independently selected from the group，comprising H，C1-C6 alkyl，C1-C6 cycloalkyl，ARYL；R6 is selected from the group:[Fo
