MOROZOV, DMITRY VALENTINOVICH,IAKOVLEV, PAVEL ANDREEVICH,CHESTNOVA, ANNA JUREVNA,REKHARSKY, MIKHAIL VLADIMIROVICH,MISHINA, MARIIA SERGEEVNA,MAKSIMENKO, ELENA ALEKSANDROVNA,KUSHAKOVA, ANNA SERGEEVNA,KO
申请号：
ARP180102251
公开号：
AR112675A1
申请日:
2018.08.07
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
This table refers to the compounds in formula (1),Either their drug salt or their stereoisomer X1 stands for N, C, CH, x2,X3，X830808 represents C (H) 8344；,NH N CR3.CHRl1，LZ each independent represents chemical link, - C (r8310)； 74952；-Is-C (O) --C (O) -O--Well-C (3DNR) -N. K, each independent check 0, 1； m stands for 0, 1, 2； R1,R3，R¹³ each independently represents H, Hal, cyano, C₁₋₆ alkyl,NH.83222；r2，R830808 the selection of each substance is independent of the category consisting of the following compounds: formula group (2),-No. 11；1. Lease land No. c833218331 and 832626；1. Replace with r830808 or not；X830909，X8310，X8311811 stands for C, CH, N； L3,L830808 represents chemical link, - C (o) -,-Is-Ch832222-，-Well-C (o) - No. 8311； No. 7491；-C (3DNH) -P = 0, 1, 2, 3, 4； r83099 represents h； Hal； cyanogen； c832183311 asphalt；C₁₋₆ alkyloxy；C₁₋₆alkyloxy C₁₋₆alkyl；Nr.8309；R8310；a. Arilo, one or more substitutes selected from Hal to replace or not to replace；C₁₋₆ alkyloxy,Nr.8309；R8310；a. 5-6 isomers containing 1-2 heteroatoms selected from N and / or o are not replaced or replaced by one or more substitutes selected from "Hal" group；C₁₋₆ alkyloxy,Nr.8309；R8310；R8310，R8310；74919；R8310；74959；each independently represents H, Hal, hydroxy, C₁₋₆-alkyl,C₁₋₆ alkyloxy；R8311th，R8311；74919；each independently represents H, C₁₋₆-alkyl；R8322，R⁹ each independently represents H, C₁₋₆ alkyl,-C (O) -NR R-CN -C (O) -ORO r831222 and r831393, together with the carbon atoms connected to them, form 5-6 heterocyclic rings composed of 1-2 heteroatoms selected from oxygen and / or nitrogen. In such rings, the heterocyclic rings composed of r831222 and r831393 may be replaced or not replaced by one or two substitutes selected from oxo group； 1. Lease land No. c833218331 and 832626；R¹⁰ each is independently selected from the group consisting of H, Hal, C₁₋₆ alkyl,hidroxi ciano alquiloxi CC83321xi-83318331-832626 asphalt c8332131-832626；-No. 83088；5-6 component heterocycle with 1-2 heteroatoms s
